Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 8, Number 1, February 2017, pages 1-6

Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis

Figure 1. Distribution of average luminal diameter narrowing across four major coronary arteries (n = 513).

**Table 1.** Participant Characteristics (n = 513)
Characteristics	Mean ± SD or percent
Age (years)	65.3 ± 11.1
Sex male	63.94%
Caucasian	98.2%
BMI (kg/m²)	30.3 ± 6.3
Current smoker	18.8%
Hypertension	65.1%
Diabetes	31.3%
Previous MI	28.0%
Family history of heart diseases	67.7%
CAD categories
Normal coronary	22.6%
Non-obstructive CAD	21.3%
Obstructive CAD	56.1%

Table 1. Participant Characteristics (n = 513)

Characteristics

Mean ± SD or percent

Age (years)

65.3 ± 11.1

Sex male

63.94%

Caucasian

98.2%

BMI (kg/m²)

30.3 ± 6.3

Current smoker

18.8%

Hypertension

65.1%

Diabetes

31.3%

Previous MI

28.0%

Family history of heart diseases

67.7%

CAD categories

Normal coronary

22.6%

Non-obstructive CAD

21.3%

Obstructive CAD

56.1%

**Table 2.** Natriuretic Peptide System SNP Genotype Frequencies
SNP ID (major allele/minor allele)	n	Genotypes
MAF: minor allele frequency.
NPPA rs5065 (A/G)	510	375 (73.5%)	119 (23.3%)	16 (3.1%)	0.15
NPPB rs198389 (A/G)	490	174 (34.2%)	257 (50.5%)	78 (15.3%)	0.42
NPR2 rs10758325 (G/A)	507	176 (34.7%)	249 (49.0%)	83 (16.3%)	0.41

Table 2. Natriuretic Peptide System SNP Genotype Frequencies

SNP ID (major allele/minor allele)

Genotypes

Homozygous major allele (n, %)

Heterozygous (n, %)

Homozygous minor allele (n, %)

MAF

MAF: minor allele frequency.

NPPA rs5065 (A/G)

510

375 (73.5%)

119 (23.3%)

16 (3.1%)

0.15

NPPB rs198389 (A/G)

490

174 (34.2%)

257 (50.5%)

78 (15.3%)

0.42

NPR2 rs10758325 (G/A)

507

176 (34.7%)

249 (49.0%)

83 (16.3%)

0.41

**Table 3.** Association of SNPs of the Natriuretic Peptide System and Obstructive CAD
SNP	Genotype	Obstructive CAD
*P < 0.05. Adjusted for age and sex.
NPPA rs5065 (n = 510)	AA	1.04 (0.88 - 1.22)	0.99 (0.83 - 1.16)	1.31 (0.88 - 1.95)	0.199
AG/GG	Reference	Reference	Reference
NPPB rs198389 (n = 509)	AA	1.00 (0.87 - 1.16)	0.93 (0.79 - 1.10)	1.50 (1.09 - 2.07)*	0.015
AG/GG	Reference	Reference	Reference
NPR2 rs10758325 (n = 508)	GG	1.02 (0.88 - 1.18)	1.04 (0.90 - 1.22)	0.90 (0.63 - 1.28)	0.443
GA/AA	Reference	Reference	Reference

Table 3. Association of SNPs of the Natriuretic Peptide System and Obstructive CAD

SNP

Genotype

Obstructive CAD

Overall RR (95% CI)

Male RR (95% CI)

Female RR (95% CI)

P-value (sex difference)

*P < 0.05. Adjusted for age and sex.

NPPA rs5065 (n = 510)

1.04 (0.88 - 1.22)

0.99 (0.83 - 1.16)

1.31 (0.88 - 1.95)

0.199

AG/GG

Reference

NPPB rs198389 (n = 509)

1.00 (0.87 - 1.16)

0.93 (0.79 - 1.10)

1.50 (1.09 - 2.07)*

0.015

AG/GG

Reference

NPR2 rs10758325 (n = 508)

1.02 (0.88 - 1.18)

1.04 (0.90 - 1.22)

0.90 (0.63 - 1.28)

0.443

GA/AA

Reference

**Table 4.** Association of SNPs of the Natriuretic Peptide System and Average Luminal Narrowing (Excluding Patients With 0% Luminal Narrowing)
SNP	Genotype	Average luminal narrowing
*P < 0.05. ^†P < 0.01. Adjusted for age and sex.
NPPA rs5065 (n = 385)	AA	1.39 (-3.43 - 6.21)	-1.37 (-7.25 - 4.51)	6.95 (-1.39 - 15.30)	0.110
AG/GG	Reference	Reference	Reference
NPPB rs198389 (n = 385)	AA	4.91 (0.50 - 9.32)*	1.92 (-3.44 - 7.28)	11.05 (3.37 - 18.73)^†	0.057
AG/GG	Reference	Reference	Reference
NPR2 rs10758325 (n = 383)	GG	0.65 (-3.84 - 5.14)	-0.37 (-5.79 - 5.05)	2.88 (-5.14 - 10.91)	0.511
GA/AA	Reference	Reference	Reference

Table 4. Association of SNPs of the Natriuretic Peptide System and Average Luminal Narrowing (Excluding Patients With 0% Luminal Narrowing)

SNP

Genotype

Average luminal narrowing

Overall β (95% CI)

Male β (95% CI)

Female β (95% CI)

P-value (sex difference)

*P < 0.05. ^†P < 0.01. Adjusted for age and sex.

NPPA rs5065 (n = 385)

1.39 (-3.43 - 6.21)

-1.37 (-7.25 - 4.51)

6.95 (-1.39 - 15.30)

0.110

AG/GG

Reference

NPPB rs198389 (n = 385)

4.91 (0.50 - 9.32)*

1.92 (-3.44 - 7.28)

11.05 (3.37 - 18.73)^†

0.057

AG/GG

Reference

NPR2 rs10758325 (n = 383)

0.65 (-3.84 - 5.14)

-0.37 (-5.79 - 5.05)

2.88 (-5.14 - 10.91)

0.511

GA/AA

Reference