Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 5, Number 1, February 2014, pages 1-7

Impact of Grapefruit Juice on the Antiplatelet Activity of Loading and Maintenance Doses of Clopidogrel in Healthy Volunteers

Tables

**Table 1.** PRU Values Following a Clopidogrel Loading Dose With Grapefruit Juice and With Tap Water
Patient	PRU
Patient	With grapefruit juice	With tap water
*P = 0.001; + = clopidogrel hyporesponders; PRU: platelet resistance unit; CI: confidence interval.
1	240+	227
2	172	101
3	290+	260+
4	161	140
5	250+	162
6	310+	260+
7	236+	89
8	253+	240+
9	225	207
10	232	100
11	260+	197
12	239+	234
13	255+	124
14	170	142
Mean (95% CI)*	235.2 (95% CI: 210.4 - 260.0)	177.4 (95% CI: 141.6 - 213.1)

**Table 2.** PRU Values Following Clopidogrel Maintenance Doses With Grapefruit Juice and With Tap Water
Patient	PRU
Patient	With grapefruit juice	With tap water
*P = 0.059; + = clopidogrel hyporesponders; PRU: platelet resistance unit; CI: confidence interval.
1	239+	92
2	299+	241+
3	74	80
4	245+	208
5	120	89
6	290+	237+
7	263+	340+
8	158	144
9	264+	170
10	99	130
11	254+	204
12	208	225
13	288+	296+
14	256+	169
15	227	206
16	126	144
17	201	189
Mean (95% CI)	212.4 (95% CI: 175.8 - 249.0)	186.1 (95% CI: 149.6 - 222.7)

**Table 3.** Side Effects Reported During Maintenance Therapy in Subjects Receiving Clopidogrel With Grapefruit Juice and With Water
Subjects	Adverse events
Subjects	Clopidogrel with water	Clopidogrel with grapefruit juice
1	Bruising	None
2	None	None
3	None	None
4	None	Bruising
5	None	None
6	Nausea	None
7	None	None
8	Diarrhea (1 episode)	None
9	None	Lower GI bleed (melena, dark tarry, stools × 2 days)
10	Diarrhea (1 episode)	None
11	Bruising; arthralgia	Arthralgia
12	None	None
13	None	Heartburn
14	Heartburn; headache	Bruising
15	Headache	Nausea
16	Epistaxis; headache	None
17	Heartburn	Heartburn
Total number of volunteers with adverse events	9 (53%)	7 (41%)