Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Review

Volume 13, Number 5, October 2022, pages 255-263

A Closer Look at the HEART Score

Tables

**Table 1.** Original HEART Score Components and Scoring
Components	Severity	Score
ECG: electrocardiogram.
History	Highly suspicious	2
	Moderately suspicious	1
	Slightly suspicious	0
ECG	Significant ST elevation	2
	Nonspecific repolarization disturbance	1
	Normal	0
Age	> 65 years	2
	45 - 65 years	1
	< 45 years	0
Risk factors	≥ 3 risk factors/history of atherosclerotic disease	2
	1 or 2 risk factors	1
	No risk factors known	0
Troponin	> 2 × normal limit	2
	1 - 2 × normal limit	1
	≤ normal limit	0

**Table 2.** HEART Score Variants and Their Components
Variants	Components	NPV	Authors
^aMultiple authors have quoted varying approaches to the modified HEART variant, but the common theme was the alteration of the troponin component. NPV: negative predictive value of low-risk groups. ECG: electrocardiogram; cTn: cardiac troponin I; hs-cTn: high-sensitivity cardiac troponin; CIT: cardiac imaging test.
HEAR score	History, ECG, age, risk factors	99.10%	Smith et al, 2020 [14]
HEART score pathway	HEAR score + serial troponin levels	99.60%	Mahler et al, 2015 [18]
Modified HEART score^a	HEAR + cTnI (cut-off < 0.02 ng/mL)	99.55%	Mark et al, 2018 [10]
	HEAR + hs-cTnT (serial 4 - 14 h/delta 1 h)	99.80%	McCord et al, 2017 [7]
	HEAR + hs-cTnI	98.60%	Sajeed et al, 2020 [15]
	HEART + 0-h/1-h hs-cTnT	99.80%	Nilsson et al, 2021 [16]
	HEAR + hs-cTnI	98.90%	Ma et al, 2016 [17]
HEART-2 score	HEART + CIT	96.90%	Schrader et al, 2022 [20]
HEARTS₃ score	Weighted HEART score + sex + serial 2-h ECG + serial 2-h delta troponin	99.40%	Francis et al, 2012 [19]