Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 12, Number 6, December 2021, pages 351-357

Cytochrome b-245 Alpha Chain Gene Variants and Arterial Function in Indonesian Short Stature Children

**Table 1.** Samples Characteristics
Variables	Frequency/mean	SD
BMI: body mass index; SD: standard deviation.
Sex
Male	80 (56.3%)
Female	62 (43.7%)
Age (years)	10.09	0.91
Height for age (z score)	-2.38	0.59
BMI (z score)	-1.38	1.03
Aortic ascending diameter during systole	1.75	0.15
Aortic ascending diameter during diastole	1.50	0.17
Aortic stiffness index	1.78	1.78
Aortic distensibility index	76.58	53.86

Table 1. Samples Characteristics

Variables

Frequency/mean

BMI: body mass index; SD: standard deviation.

Sex

Male

80 (56.3%)

Female

62 (43.7%)

Age (years)

10.09

0.91

Height for age (z score)

-2.38

0.59

BMI (z score)

-1.38

1.03

Aortic ascending diameter during systole

1.75

0.15

Aortic ascending diameter during diastole

1.50

0.17

Aortic stiffness index

1.78

Aortic distensibility index

76.58

53.86

**Table 2.** Allele Frequencies
No.	SNV	Genotype	Frequency	Percentage
SNV: single nucleotide variant.
1.	rs4673 (242C>T)	CC	107	75.35%
		CT	30	21.13%
		TT	5	3.52%
	Allele frequency	C	244	85.92%
		T	40	14.08%
2.	rs1049255 (640A>G)	AA	63	45.00%
		AG	62	44.29%
		GG	15	10.71%
	Allele frequency	A	188	71.63%
		G	92	28.37%
3.	rs9932581 (-930A>G)	AA	69	48.94%
		AG	64	45.39%
		GG	8	5.67%
	Allele frequency	A	202	71.63%
		G	80	28.37%
4.	rs7195830 (*49A>G)	AA	12	8.63%
		GA	59	42.45%
		GG	68	48.92%
	Allele frequency	A	83	29.86%
		G	195	70.14%

Table 2. Allele Frequencies

No.

SNV

Genotype

Frequency

Percentage

SNV: single nucleotide variant.

rs4673 (242C>T)

107

75.35%

21.13%

3.52%

Allele frequency

244

85.92%

14.08%

rs1049255 (640A>G)

45.00%

44.29%

10.71%

Allele frequency

188

71.63%

28.37%

rs9932581 (-930A>G)

48.94%

45.39%

5.67%

Allele frequency

202

71.63%

28.37%

rs7195830 (*49A>G)

8.63%

42.45%

48.92%

Allele frequency

29.86%

195

70.14%

**Table 3.** Association Between Genotypes and Aortic Stiffness Index
SNV	Genotype	Mean of aortic stiffness index	P
*P < 0.05. ^aANOVA. ^bKruskal-Wallis. ^ct-test. ANOVA: analysis of variance; SNV: single nucleotide variant.
rs4673 (242C>T)	CC	2.39 ± 0.54	0.623^a
	CT	2.29 ± 0.54
	TT	2.48 ± 1.07
	CC + CT	2.37 ± 0.54	0.74^c
	TT	2.45 ± 1.09
rs1049255 (640A>G)	AA	2.31 ± 0.50	0.191^a
	AG	2.47 ± 0.57
	GG	2.25 ± 0.76
	AA + AG	2.39 ± 0.54	0.372^c
	GG	2.25 ± 0.76
rs9932581 (-930A>G)	AA	2.35 ± 0.48	0.048^a*
	AG	2.45 ± 0.61
	GG	1.93 ± 0.70
	AA + AG	2.367 ± 0.55	0.026^c*
	GG	1.93 ± 0.70
rs7195830 (*49A>G)	AA	2.32 ± 0.25	0.805^b
	AG	2.33 ± 0.46
	GG	2.43 ± 0.68
	AA + AG	2.33 ± 0.43	0.335^c
	GG	2.43 ± 0.68

Table 3. Association Between Genotypes and Aortic Stiffness Index

SNV

Genotype

Mean of aortic stiffness index

*P < 0.05. ^aANOVA. ^bKruskal-Wallis. ^ct-test. ANOVA: analysis of variance; SNV: single nucleotide variant.

rs4673 (242C>T)

2.39 ± 0.54

0.623^a

2.29 ± 0.54

2.48 ± 1.07

CC + CT

2.37 ± 0.54

0.74^c

2.45 ± 1.09

rs1049255 (640A>G)

2.31 ± 0.50

0.191^a

2.47 ± 0.57

2.25 ± 0.76

AA + AG

2.39 ± 0.54

0.372^c

2.25 ± 0.76

rs9932581 (-930A>G)

2.35 ± 0.48

0.048^a*

2.45 ± 0.61

1.93 ± 0.70

AA + AG

2.367 ± 0.55

0.026^c*

1.93 ± 0.70

rs7195830 (*49A>G)

2.32 ± 0.25

0.805^b

2.33 ± 0.46

2.43 ± 0.68

AA + AG

2.33 ± 0.43

0.335^c

2.43 ± 0.68

**Table 4.** Association Between Genotypes and Aortic Distensibility
SNV	Genotype	Mean of aortic distensibility	P
*P < 0.05. ^aANOVA. ^bt-test. ANOVA: analysis of variance; SNV: single nucleotide variant.
rs4673 (242C>T)	CC	69.29 ± 39.34	0.263^a
	CT	81.31 ± 37.82
	TT	78.25 ± 34.50
	CC + CT	68.26 ± 38.18	0.206^b
	TT	78.25 ± 34.50
rs1049255 (640A>G)	AA	74.25 ± 42.69	0.410^a
	AG	67.88 ± 37.28
	GG	82.17 ± 34.45
	AA + AG	69.42 ± 38.22	0.235^b
	GG	82.17 ± 34.45
rs9932581 (-930A>G)	AA	71.19 ± 33.42	0.044^a*
	AG	70.11 ± 40.13
	GG	150.67 ± 72.97
	AA + AG	69.12 ± 34.69	0.013^b*
	GG	150.67 ± 72.97
rs7195830 (*49A>G)	AA	65.62 ± 23.39	0.605^a
	AG	75.58 ± 37.89
	GG	69.49 ± 40.15
	AA + AG	73.89 ± 35.91	0.260^b
	GG	69.49 ± 40.15

Table 4. Association Between Genotypes and Aortic Distensibility

SNV

Genotype

Mean of aortic distensibility

*P < 0.05. ^aANOVA. ^bt-test. ANOVA: analysis of variance; SNV: single nucleotide variant.

rs4673 (242C>T)

69.29 ± 39.34

0.263^a

81.31 ± 37.82

78.25 ± 34.50

CC + CT

68.26 ± 38.18

0.206^b

78.25 ± 34.50

rs1049255 (640A>G)

74.25 ± 42.69

0.410^a

67.88 ± 37.28

82.17 ± 34.45

AA + AG

69.42 ± 38.22

0.235^b

82.17 ± 34.45

rs9932581 (-930A>G)

71.19 ± 33.42

0.044^a*

70.11 ± 40.13

150.67 ± 72.97

AA + AG

69.12 ± 34.69

0.013^b*

150.67 ± 72.97

rs7195830 (*49A>G)

65.62 ± 23.39

0.605^a

75.58 ± 37.89

69.49 ± 40.15

AA + AG

73.89 ± 35.91

0.260^b

69.49 ± 40.15