Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 9, Number 2, April 2018, pages 94-98

The Impact of Admission Serum Creatinine on Major Adverse Clinical Events in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

**Table 1.** Demographics and Clinical Characteristics of Patients
Clinical characteristics	SCr ≥ 1.2 (n = 148)	SCr < 1.2 (n = 508)	P value
Scr: serum creatinine at admission; BMI: body mass index; eGFR: estimated glomerular filtration rate; Hx: history; MI: myocardial infarction; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting; TIA: transient ischemic attack; A fib: atrial fibrillation; A flutter: atrial flutter.
Age (years) (mean ± SD)	66.84 ± 13.66	59.45 ± 11.70	< 0.0001
Sex male (%)	81.76 (n = 121)	69.69 (n = 354)
BMI (mean ± SD)	28.51 ± 5.55	29.54 ± 6.42	0.08
Caucasian race (%)	89.19 (n = 132)	88.5 (n = 450)	0.82
African American race (%)	9.46 (n = 14)	10.24 (n = 52)	0.78
Hispanic race (%)	0 (n = 0)	0.20 (n = 1)	0.59
Other race (%)	0.68 (n = 1)	0.79 (n = 4)
Unkown race (%)	0.68 (n = 1)	0.20 (n = 1)
Initial creatinine (mg/dL) (mean ± SD)	1.82 ± 1.88	0.89 ± 0.16	< 0.0001
eGFR (mL/min/1.73 m²) (mean ± SD)	48.36 ± 16.08	87.37 ± 16.53	<0.0001
Initial troponin	4.79 ± 13.05	4.67 ± 19.53	0.944
Peak troponin	83.1 ± 71.29	71.22 ± 66.78	0.0612
Hx of hypertension (%)	74.32 (n = 110)	59.64 (n = 303)	< 0.005
Hx of smoker (%)	35.81 (n = 53)	52.75 (n = 268)	< 0.0005
Current heart failure (%)	4.05 (n = 6)	2.75 (n = 14)	0.42
Hx of dyslipidemia (%)	64.86 (n = 96)	47.63 (n = 242)	< 0.0005
Hx of chronic lung disease (%)	10.13 (n = 15)	7.08 (n = 36)	0.22
Hx of diabetes (%)	22.97 (n = 34)	18.5 (n = 97)	0.23
Hx of prior MI (%)	29.72 (n = 44)	18.3 (n = 93)	< 0.005
Hx of prior heart failure (%)	8.78 (n = 13)	3.74 (n = 19)	< 0.05
Hx of A fib/A flutter (%)	3.37 (n = 5)	1.18 (n = 6)	0.07
Hx of prior PCI (%)	27.7 (n = 41)	17.51 (n = 89)	< 0.01
Hx of prior CABG (%)	13.51 (n = 20)	6.88 (n = 35)	< 0.05
Hx of cerebrovascular stroke (%)	8.1 (n = 12)	3.74 (n = 19)	< 0.05
Hx of cerebrovascular disease (%)	15.54 (n = 23)	5.51 (n = 28)	< 0.0005
Hx of peripheral arterial disease (%)	14.18 (n = 21)	5.7 (n = 29)	< 0.001
Hx of current dialysis (%)	2.02 (n = 3)	0 (n = 0)
Hx of cerebrovascular TIA (%)	3.38 (n = 5)	0.79 (n = 4)	< 0.05

Table 1. Demographics and Clinical Characteristics of Patients

Clinical characteristics

SCr ≥ 1.2 (n = 148)

SCr < 1.2 (n = 508)

P value

Scr: serum creatinine at admission; BMI: body mass index; eGFR: estimated glomerular filtration rate; Hx: history; MI: myocardial infarction; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting; TIA: transient ischemic attack; A fib: atrial fibrillation; A flutter: atrial flutter.

Age (years) (mean ± SD)

66.84 ± 13.66

59.45 ± 11.70

< 0.0001

Sex male (%)

81.76 (n = 121)

69.69 (n = 354)

BMI (mean ± SD)

28.51 ± 5.55

29.54 ± 6.42

0.08

Caucasian race (%)

89.19 (n = 132)

88.5 (n = 450)

0.82

African American race (%)

9.46 (n = 14)

10.24 (n = 52)

0.78

Hispanic race (%)

0 (n = 0)

0.20 (n = 1)

0.59

Other race (%)

0.68 (n = 1)

0.79 (n = 4)

Unkown race (%)

0.68 (n = 1)

0.20 (n = 1)

Initial creatinine (mg/dL) (mean ± SD)

1.82 ± 1.88

0.89 ± 0.16

< 0.0001

eGFR (mL/min/1.73 m²) (mean ± SD)

48.36 ± 16.08

87.37 ± 16.53

<0.0001

Initial troponin

4.79 ± 13.05

4.67 ± 19.53

0.944

Peak troponin

83.1 ± 71.29

71.22 ± 66.78

0.0612

Hx of hypertension (%)

74.32 (n = 110)

59.64 (n = 303)

< 0.005

Hx of smoker (%)

35.81 (n = 53)

52.75 (n = 268)

< 0.0005

Current heart failure (%)

4.05 (n = 6)

2.75 (n = 14)

0.42

Hx of dyslipidemia (%)

64.86 (n = 96)

47.63 (n = 242)

< 0.0005

Hx of chronic lung disease (%)

10.13 (n = 15)

7.08 (n = 36)

0.22

Hx of diabetes (%)

22.97 (n = 34)

18.5 (n = 97)

0.23

Hx of prior MI (%)

29.72 (n = 44)

18.3 (n = 93)

< 0.005

Hx of prior heart failure (%)

8.78 (n = 13)

3.74 (n = 19)

< 0.05

Hx of A fib/A flutter (%)

3.37 (n = 5)

1.18 (n = 6)

0.07

Hx of prior PCI (%)

27.7 (n = 41)

17.51 (n = 89)

< 0.01

Hx of prior CABG (%)

13.51 (n = 20)

6.88 (n = 35)

< 0.05

Hx of cerebrovascular stroke (%)

8.1 (n = 12)

3.74 (n = 19)

< 0.05

Hx of cerebrovascular disease (%)

15.54 (n = 23)

5.51 (n = 28)

< 0.0005

Hx of peripheral arterial disease (%)

14.18 (n = 21)

5.7 (n = 29)

< 0.001

Hx of current dialysis (%)

2.02 (n = 3)

0 (n = 0)

Hx of cerebrovascular TIA (%)

3.38 (n = 5)

0.79 (n = 4)

< 0.05

**Table 2.** Adverse Clinical Outcomes Based on Admission Serum Creatinine and eGFR
Adverse outcomes	SCr ≥ 1.2 (n = 148)	SCr < 1.2 (n = 508)	P value	eGFR ≥ 60 (n = 527)	eGFR < 60 (n = 129)	P value
SCr: serum creatinine at admission; V Tach: ventricular tachycardia; V Fib: ventricular fibrillation; CVA: cerebrovascular accident; eGFR: estimated glomerular filtration rate at admission.
Initial troponin				4.52 ± 19.23	5.40 ± 13.61	0.624
Peak troponin				69.40 ± 65.51	92.50 ± 74.65	< 0.001
Atrial fibrillation (%)	1.35 (n = 2)	1.37 (n = 7)	0.9853	1.13 (n = 6)	2.32 (n = 3)	0.2967
V Tach/V Fib (%)	3.37 (n = 5)	2.55 (n = 13)	0.5907	2.46 (n = 13)	3.87 (n = 5)	0.3794
New dialysis (%)	0 (n = 0)	0.39 (n = 2)	0.4471	0.37 (n = 2)	0 (n = 0)	0.4893
Mechanical ventilation (%)	0.67 (n = 1)	0.78 (n = 4)	0.8919	0.75 (n = 4)	0.77 (n = 1)	0.9812
Cardiogenic shock (%)	11.48 (n = 17)	6.29 (n = 32)	< 0.05	5.69 (n = 30)	14.72 (n = 19)	< 0.001
Heart failure (%)	15.54 (n = 23)	6.69 (n = 34)	< 0.005	6.45 (n = 34)	17.82 (n = 23)	< 0.0005
Bleeding (%)	8.78 (n = 13)	3.93 (n = 20)	< 0.05	3.6 (n = 19)	10.85 (n = 14)	< 0.001
CVA (%)	0.67 (n = 1)	0.79 (n = 4)	0.8827	0.57 (n = 3)	1.55 (n = 2)	0.2519
Mortality (%)	6.08 (n = 9)	4.72 (n = 7)	0.5055	1.33 (n = 7)	6.98 (n = 9)	< 0.0005

Table 2. Adverse Clinical Outcomes Based on Admission Serum Creatinine and eGFR

Adverse outcomes

SCr ≥ 1.2 (n = 148)

SCr < 1.2 (n = 508)

P value

eGFR ≥ 60 (n = 527)

eGFR < 60 (n = 129)

P value

SCr: serum creatinine at admission; V Tach: ventricular tachycardia; V Fib: ventricular fibrillation; CVA: cerebrovascular accident; eGFR: estimated glomerular filtration rate at admission.

Initial troponin

4.52 ± 19.23

5.40 ± 13.61

0.624

Peak troponin

69.40 ± 65.51

92.50 ± 74.65

< 0.001

Atrial fibrillation (%)

1.35 (n = 2)

1.37 (n = 7)

0.9853

1.13 (n = 6)

2.32 (n = 3)

0.2967

V Tach/V Fib (%)

3.37 (n = 5)

2.55 (n = 13)

0.5907

2.46 (n = 13)

3.87 (n = 5)

0.3794

New dialysis (%)

0 (n = 0)

0.39 (n = 2)

0.4471

0.37 (n = 2)

0 (n = 0)

0.4893

Mechanical ventilation (%)

0.67 (n = 1)

0.78 (n = 4)

0.8919

0.75 (n = 4)

0.77 (n = 1)

0.9812

Cardiogenic shock (%)

11.48 (n = 17)

6.29 (n = 32)

< 0.05

5.69 (n = 30)

14.72 (n = 19)

< 0.001

Heart failure (%)

15.54 (n = 23)

6.69 (n = 34)

< 0.005

6.45 (n = 34)

17.82 (n = 23)

< 0.0005

Bleeding (%)

8.78 (n = 13)

3.93 (n = 20)

< 0.05

3.6 (n = 19)

10.85 (n = 14)

< 0.001

CVA (%)

0.67 (n = 1)

0.79 (n = 4)

0.8827

0.57 (n = 3)

1.55 (n = 2)

0.2519

Mortality (%)

6.08 (n = 9)

4.72 (n = 7)

0.5055

1.33 (n = 7)

6.98 (n = 9)

< 0.0005