Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 9, Number 1, February 2018, pages 22-27

Early Diagnosis and Treatment of Coronary Heart Disease in Asymptomatic Subjects With Advanced Vascular Atherosclerosis of the Carotid Artery (Type III and IV b Findings Using Ultrasound) and Risk Factors

**Table 1.** Test Results of the 43 Asymptomatic Subjects With a Type III or IV b Finding in the Ultrasound Examination
Sex	Age	PROCAM	TPA	Plaque thickness	Type ultrasound	Symptoms	Risk factors	Diagnostics	Coronary result	Therapy	Exercise ECG
M	58	15.20%	199	2.7	IV b	none	LDL,	exercise-ECG, Coro	smooth vessels	conservative	negative
W	57	6.53%	135	2.6	IV b	none	LDL, FA	CT	smooth vessels	conservative
M	37	0.78%	65	2.3	IV b	none	LDL	CT	smooth vessels	conservative
M	47	13.66%	182	2.8	IV b	none	LDL	CT	smooth vessels	conservative
M	56	27.50%	128	2.7	IV b	none	HDL, FA	CT	smooth vessels	conservative
M	48	21.54%	156	2.6	IV b	none	LDL, FA	CT	sclerosis	conservative
M	59	30.80%	182	2.9	IV b	none	LDL, HDL, FA	CT	sclerosis	conservative
M	53	13.44%	119	2.3	IV b	none	HDL, FA	CT	sclerosis	conservative
W	57	7.00%	94	3.8	III	none	LDL, FA	CT	sclerosis	conservative
M	54	19.96%	217	3.2	IV b	none	HDL, FA	CT	sclerosis	conservative
W	57	2.17%	171	3.0	IV b	none	LDL, FA	CT	sclerosis	conservative
M	60	28.43%	135	3.4	IV b	none	LDL	CT	30% HS	conservative
M	49	24.59%	80	2.1	IV b	none	LDL, FA	CT	30% LAD	conservative
W	56	4.07%	128	4.2	IV b	none	LDL, FA	CT	30% LAD	conservative
W	59	4.94%	159	3.2	IV b	none	LDL	CT	30% LAD, RCX	conservative
W	61	33.21%	177	2.8	IV b	none	LDL, FA	CT	30% LAD, RCX	conservative
M	59	10.53%	218	3.6	IV b	none	HDL, FA	CT	30% LAD, RCX	conservative
M	46	3.90%	106	4.1	IV b	none	LDL	CT	30% RCA	conservative
M	52	4.00%	128	3.5	IV b	none	FA	exercise-ECG, CT	30% LAD	conservative	negative
M	49	11.62%	127	4.5	IV b	none	HDL, FA	CT	30-50% RCX	conservative
M	58	30.44%	332	3.3	IV b	none	HDL, FA	CT	50% LAD	conservative
M	53	24.67%	159	3.0	IV b	none	LDL	CT	50% RCA	conservative
M	62	35.60%	131	2.3	IV b	none	LDL	CT	50% RCA,RCX	conservative
M	47	3.04%	90	2.1	IV b	none	LDL,	Coro	50% RCX	conservative
W	58	36.90%	185	2.4	IV b	none	LDL, DM, FA	exercise-ECG, CT	50% LAD	conservative	negative
M	53	7.55%	193	3.5	IV b	none	LDL	CT	50% RCA, LAD	conservative
M	58	5.12%	137	2.5	IV b	none	none	CT	50% LAD,RCA	conservative
M	64	16.92%	164	3.6	IV b	none	HDL, FA	CT, Coro	50-70% 3GE	conservative
M	61	19.49%	156	4.6	IV b	none	HDL, FA	CT	60-70% LAD	conservative
M	44	15.82%	122	2.3	IV b	none	LDL, HDL	exercise-ECG, CT, Coro	60-70% LAD, RCX	conservative	negative
M	55	5.88%	91	3.8	III	none	FA	exercise-ECG, CT, Coro	70% LAD	conservative	negative
M	62	38.96%	145	3.7	IV b	none	HDL	CT, Coro	70% LAD,RCA	conservative
M	59	29.73%	148	3.3	IV b	none	HDL, FA	CT	70-90% LAD	conservative
W	46	3.11%	54	3.5	III	none	LDL	exercise-ECG, CT, Coro	75% RCX, 60% LAD	conservative	negative
M	60	36.37%	172	3.5	IV b	none	LDL	CT, Coro	90% RCX	conservative
M	52	6.04%	228	3.1	IV b	none	HDL, FA	CT	70-80% LAD, RCA	conservative
M	63	3.95%	131	2.2	IV b	none	none	exercise-ECG, CT, coro	70-80% LAD, 3 GE	stenting	pathological
M	57	26.55%	165	2.3	IV b	none	LDL, FA	CT, Coro	70% LAD	stenting	pathological
M	56	37.51%	110	2.8	IV b	none	HDL, FA	CT, Coro	70-90% RCA,LAD	stenting
M	61	23.07%	255	3.7	IV b	none	LDL	CT, Coro	90% 3 GE	stenting	negative
M	52	16.37%	210	4.0	IV b	none	LDL, HDL	CT, Coro	100% RCA, 3 GE	stenting
M	63	14.66%	221	2.5	IV b	none	HDL, FA	Coro	80% HS, 3-GE	bypass	pathological
M	49	23.29%	138	3.1	IV b	none	LDL, HDL	CT, Coro	100% RCX,RCA, 3-GE, HS	bypass

Table 1. Test Results of the 43 Asymptomatic Subjects With a Type III or IV b Finding in the Ultrasound Examination

Sex

Age

PROCAM

TPA

Plaque thickness

Type ultrasound

Symptoms

Risk factors

Diagnostics

Coronary result

Therapy

Exercise ECG

15.20%

199

2.7

IV b

none

LDL,

exercise-ECG, Coro

smooth vessels

conservative

negative

6.53%

135

2.6

IV b

none

LDL, FA

smooth vessels

conservative

0.78%

2.3

IV b

none

LDL

smooth vessels

conservative

13.66%

182

2.8

IV b

none

LDL

smooth vessels

conservative

27.50%

128

2.7

IV b

none

HDL, FA

smooth vessels

conservative

21.54%

156

2.6

IV b

none

LDL, FA

sclerosis

conservative

30.80%

182

2.9

IV b

none

LDL, HDL, FA

sclerosis

conservative

13.44%

119

2.3

IV b

none

HDL, FA

sclerosis

conservative

7.00%

3.8

III

none

LDL, FA

sclerosis

conservative

19.96%

217

3.2

IV b

none

HDL, FA

sclerosis

conservative

2.17%

171

3.0

IV b

none

LDL, FA

sclerosis

conservative

28.43%

135

3.4

IV b

none

LDL

30% HS

conservative

24.59%

2.1

IV b

none

LDL, FA

30% LAD

conservative

4.07%

128

4.2

IV b

none

LDL, FA

30% LAD

conservative

4.94%

159

3.2

IV b

none

LDL

30% LAD, RCX

conservative

33.21%

177

2.8

IV b

none

LDL, FA

30% LAD, RCX

conservative

10.53%

218

3.6

IV b

none

HDL, FA

30% LAD, RCX

conservative

3.90%

106

4.1

IV b

none

LDL

30% RCA

conservative

4.00%

128

3.5

IV b

none

exercise-ECG, CT

30% LAD

conservative

negative

11.62%

127

4.5

IV b

none

HDL, FA

30-50% RCX

conservative

30.44%

332

3.3

IV b

none

HDL, FA

50% LAD

conservative

24.67%

159

3.0

IV b

none

LDL

50% RCA

conservative

35.60%

131

2.3

IV b

none

LDL

50% RCA,RCX

conservative

3.04%

2.1

IV b

none

LDL,

Coro

50% RCX

conservative

36.90%

185

2.4

IV b

none

LDL, DM, FA

exercise-ECG, CT

50% LAD

conservative

negative

7.55%

193

3.5

IV b

none

LDL

50% RCA, LAD

conservative

5.12%

137

2.5

IV b

none

50% LAD,RCA

conservative

16.92%

164

3.6

IV b

none

HDL, FA

CT, Coro

50-70% 3GE

conservative

19.49%

156

4.6

IV b

none

HDL, FA

60-70% LAD

conservative

15.82%

122

2.3

IV b

none

LDL, HDL

exercise-ECG, CT, Coro

60-70% LAD, RCX

conservative

negative

5.88%

3.8

III

none

exercise-ECG, CT, Coro

70% LAD

conservative

negative

38.96%

145

3.7

IV b

none

HDL

CT, Coro

70% LAD,RCA

conservative

29.73%

148

3.3

IV b

none

HDL, FA

70-90% LAD

conservative

3.11%

3.5

III

none

LDL

exercise-ECG, CT, Coro

75% RCX, 60% LAD

conservative

negative

36.37%

172

3.5

IV b

none

LDL

CT, Coro

90% RCX

conservative

6.04%

228

3.1

IV b

none

HDL, FA

70-80% LAD, RCA

conservative

3.95%

131

2.2

IV b

none

exercise-ECG, CT, coro

70-80% LAD, 3 GE

stenting

pathological

26.55%

165

2.3

IV b

none

LDL, FA

CT, Coro

70% LAD

stenting

pathological

37.51%

110

2.8

IV b

none

HDL, FA

CT, Coro

70-90% RCA,LAD

stenting

23.07%

255

3.7

IV b

none

LDL

CT, Coro

90% 3 GE

stenting

negative

16.37%

210

4.0

IV b

none

LDL, HDL

CT, Coro

100% RCA, 3 GE

stenting

14.66%

221

2.5

IV b

none

HDL, FA

Coro

80% HS, 3-GE

bypass

pathological

23.29%

138

3.1

IV b

none

LDL, HDL

CT, Coro

100% RCX,RCA, 3-GE, HS

bypass

**Table 2.** Baseline Characteristics of All Subjects Between the Ages of 35 to 64 Years
Characteristics	Male without type III, IV b n = 2,688	Male with type III, IV b n = 382	Female without type III, IV b n = 1,898	Female with type III, IV b n = 82
Age	48 ± 7	54 ± 6	49 ± 7	54 ± 5
BMI, weight	27.33 ± 3.97	27.96 ± 4.20	25.25 ± 4.79	25.07 ± 4.19
Smoker	610 (22.7%)	165 (43.2%)	383 (20.2%)	38 (46.3%)
LDL-cholesterol	150 ± 34	158 ± 39	141 ± 33	161 ± 39
HDL-cholesterol	51 ± 12	48 ± 11	65 ± 15	62 ± 14
Triglyceride	170 ± 121	190 ± 120	109 ± 58	136 ± 71
Systolic blood pressure	127 ± 15	135 ± 18	121 ± 17	130 ± 19
Diastolic blood pressure	81 ± 8	84 ± 9	78 ± 9	79 ± 12
Diabetes	91 (3.4%)	32 (8.4%)	28 (1.5%)	5 (6.1%)
Treated blood pressure	514 (19.1%)	139 (36.4%)	313 (16.5%)	34 (41.5%)
Positive family history	573 (21.3%)	108 (28.3%)	521 (27.4%)	33 (40.2%)
Total plaque area (TPA mm²)	30 ± 34	150 ± 63	17 ± 24	120 ± 62
Max plaque thickness (mm)	1.7 ± 0.5	3.0 ± 0.8	1.6 ± 0.5	3.2 ± 0.6
PROCAM-risk	6.02% ± 6.74%	13.32% ± 10.29%	1.35% ± 2.4%	4.81% ± 6.63%
Sick (≥ 30% stenosis, infarction etc).	13 (0.5%)	98 (25.6%)	2 (0.1%)	12 (14.6%)

Table 2. Baseline Characteristics of All Subjects Between the Ages of 35 to 64 Years

Characteristics

Male without type III, IV b n = 2,688

Male with type III, IV b n = 382

Female without type III, IV b n = 1,898

Female with type III, IV b n = 82

Age

48 ± 7

54 ± 6

49 ± 7

54 ± 5

BMI, weight

27.33 ± 3.97

27.96 ± 4.20

25.25 ± 4.79

25.07 ± 4.19

Smoker

610 (22.7%)

165 (43.2%)

383 (20.2%)

38 (46.3%)

LDL-cholesterol

150 ± 34

158 ± 39

141 ± 33

161 ± 39

HDL-cholesterol

51 ± 12

48 ± 11

65 ± 15

62 ± 14

Triglyceride

170 ± 121

190 ± 120

109 ± 58

136 ± 71

Systolic blood pressure

127 ± 15

135 ± 18

121 ± 17

130 ± 19

Diastolic blood pressure

81 ± 8

84 ± 9

78 ± 9

79 ± 12

Diabetes

91 (3.4%)

32 (8.4%)

28 (1.5%)

5 (6.1%)

Treated blood pressure

514 (19.1%)

139 (36.4%)

313 (16.5%)

34 (41.5%)

Positive family history

573 (21.3%)

108 (28.3%)

521 (27.4%)

33 (40.2%)

Total plaque area (TPA mm²)

30 ± 34

150 ± 63

17 ± 24

120 ± 62

Max plaque thickness (mm)

1.7 ± 0.5

3.0 ± 0.8

1.6 ± 0.5

3.2 ± 0.6

PROCAM-risk

6.02% ± 6.74%

13.32% ± 10.29%

1.35% ± 2.4%

4.81% ± 6.63%

Sick (≥ 30% stenosis, infarction etc).

13 (0.5%)

98 (25.6%)

2 (0.1%)

12 (14.6%)