Figure 1. (a) Chemical structure of fenofibrate and fenofibric acid; (b) Comparison of fenofibrate formulations.
| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc |
| Journal website https://www.cardiologyres.org |
Review
Volume 4, Number 2, April 2013, pages 47-55
A Review of Currently Available Fenofibrate and Fenofibric Acid Formulations
Figure
Table
| Trade Name (Company) | Form and Doses, mg | Food Effect | Equivalence | Statin Coadministration |
|---|---|---|---|---|
| IDD-P: insoluble drug delivery microparticle. | ||||
| Non-micronized fenofibrate | ||||
| Fenoglide [25] (Santarus) | Tablet 40, 120 | Yes | 3 × 40 mg or single 120 mg equivalent to 130 mg fenofibrate capsule (high-fat fed conditions) | Not approved |
| Lipofen [24] (Kowa) | Capsule (Lidose) 50, 150 | Yes | 150 mg equivalent to 160 mg Tricor (low-fat and high-fat fed conditions) | Not approved |
| Lofibra [23] (Gate) | Tablet 54, 160 | Yes | 54 mg equivalent to 67 mg fenofibrate tablet; 160 mg equivalent to 200 mg fenofibrate capsule (fed conditions) | Not approved |
| Triglide [27] (Shionogi) | Tablet (IDD-P) 50, 160 | Yes | 160 mg equivalent to 200 mg micronized fenofibrate capsule (low-fat fed conditions), but absorption rate is 32% faster | Not approved |
| Fenofibrate [30] (Global Pharmaceutical) | Tablet 54, 160 | Yes | 3 × 48 mg or single 145 mg equivalent to 200 mg fenofibrate capsule (fed conditions) | Not approved |
| Fenofibrate [31] (Mylan) | Tablet 54, 160 | Yes | 54 mg equivalent to 67 mg fenofibrate capsule; 160 mg equivalent to 200 mg fenofibrate capsule (fed conditions) | Not approved |
| Fenofibrate [32] (Ranbaxy Pharmaceuticals) | Tablet 54, 160 | Yes | 54 mg equivalent to 67 mg fenofibrate capsule; 160 mg equivalent to 200 mg fenofibrate capsule (fed conditions) | Not approved |
| Micronized fenofibrate | ||||
| Antara [29] (Lupin) | Capsule 43, 130 | No | 130 mg equivalent to 200 mg fenofibrate capsule (low-fat fed conditions) | Not approved |
| Tricor [33] (Abbott Laboratories) | Capsule 67, 200 | Yes | No data | Not approved |
| Lofibra [23] (Gate) | Capsule 67, 134, 200 | Yes | 67 mg equivalent to 100 mg non-micronized fenofibrate | Not approved |
| Fenofibrate-micronized [34] (Global Pharmaceutical) | Capsule 67, 134, 200 | Yes | 67 mg equivalent to 100 mg non-micronized fenofibrate | Not approved |
| Nanocrystal fenofibrate | ||||
| Tricor [35] (Abbott) | Tablet 48, 145 | No | 3 × 48 mg or 145 mg equivalent to 200 mg micronized fenofibrate capsule (fed conditions) | Not approved |
| Fenofibric acid | ||||
| Trilipix [22] (Abbott) | Capsule (delayed release) 45, 135 | No | 135 mg equivalent to 200 mg micronized fenofibrate capsule (fed conditions) | Approved |